Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC039
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-08-09 10:22
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment tbl Madopar a 250mg 1/2+1/4+1/4+1/4 caps Madopar HBS a 125mg jedna uvece pre spavanja Older patient

Overall Assessment

non PD

Subject performance similar to non PD population

Clinical context

In the clinical reference population, 22 individuals with a value less than 0.59 were subsequently diagnosed with PD. That is, 52.38% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.59 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 10, 'TN': 9, 'TP': 32, 'FP': 21}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 10, 'TN': 11, 'TP': 32, 'FP': 19}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 40, 'TN': 29, 'TP': 2, 'FP': 1}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 5, 'TN': 4, 'TP': 37, 'FP': 26}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 8.496
timePerCircleCoV 0.0821545
timePerCircleSlope -0.0175769
meanError 1.50618
tremorFreq 5.56641
tremorRelPower 37.6911
tremorGyroAmpMean 0.0220426
tremorGyroAmpSlope 0.00123055
tremorGyroAmpCoV 0.316615
tremorCoordAmpMean 0.0553707
tremorCoordAmpSlope 0.00330867
tremorCoordAmpCoV 0.232217
tremorAccAmpMean 0.055986
tremorAccAmpSlope 0.00133969
tremorAccAmpCoV 0.171421
tremorPcRelVar 0.742801
tremorPcX -0.191437
tremorPcY -0.981505

Circle Segment 1

Duration 10.24 s, Accuracy Estimate 2.075 (lower is better)

Circle Segment 2

Duration 8.24 s, Accuracy Estimate 1.583 (lower is better)

Circle Segment 3

Duration 8.24 s, Accuracy Estimate 1.164 (lower is better)

Circle Segment 4

Duration 8.8 s, Accuracy Estimate 1.383 (lower is better)

Circle Segment 5

Duration 8.72 s, Accuracy Estimate 0.981 (lower is better)

Circle Segment 6

Duration 8.04 s, Accuracy Estimate 1.438 (lower is better)

Circle Segment 7

Duration 8.64 s, Accuracy Estimate 1.232 (lower is better)

Circle Segment 8

Duration 8.08 s, Accuracy Estimate 1.205 (lower is better)

Circle Segment 9

Duration 8.24 s, Accuracy Estimate 1.382 (lower is better)

Circle Segment 10

Duration 7.72 s, Accuracy Estimate 2.619 (lower is better)

Spiral

numSpirals 5
timePerSpiralMean 49.2
timePerSpiralCoV 0.181263
timePerSpiralSlope 0.106341
meanError 2.08543
tremorFreq 6.15234
tremorRelPower 37.8617
tremorGyroAmpMean 0.0269223
tremorGyroAmpSlope -0.000235724
tremorGyroAmpCoV 0.457951
tremorCoordAmpMean 0.0429678
tremorCoordAmpSlope -0.00191101
tremorCoordAmpCoV 0.396435
tremorAccAmpMean 0.0754721
tremorAccAmpSlope -0.000601939
tremorAccAmpCoV 0.133839
tremorPcRelVar 0.564793
tremorPcX -0.0512566
tremorPcY 0.998686

Spiral Segment 1

Duration 41.76 s, Accuracy Estimate 1.716 (lower is better)

Spiral Segment 2

Duration 38.64 s, Accuracy Estimate 2.065 (lower is better)

Spiral Segment 3

Duration 49.96 s, Accuracy Estimate 1.949 (lower is better)

Spiral Segment 4

Duration 56.8 s, Accuracy Estimate 1.957 (lower is better)

Spiral Segment 5

Duration 58.84 s, Accuracy Estimate 2.74 (lower is better)

Elel

eDurationMean 0.823889
eDurationStd 0.213485
eDurationStdnorm 0.259119
eDurationMedian 0.78
eDurationQuartdelta 0.305
eDurationQuartdeltanorm 0.391026
eDurationKurt 4.15447
eDurationTrenddiff 0.01
eDurationTrendratio 1.01294
eWidthMean 4.88475
eWidthStd 0.636165
eWidthStdnorm 0.130235
eWidthMedian 4.797
eWidthQuartdelta 0.819
eWidthQuartdeltanorm 0.170732
eWidthKurt 3.44223
eWidthTrenddiff 0.585
eWidthTrendratio 1.125
eHeightMean 6.6755
eHeightStd 0.793998
eHeightStdnorm 0.118942
eHeightMedian 6.6105
eHeightQuartdelta 0.9945
eHeightQuartdeltanorm 0.150442
eHeightKurt 2.55477
eHeightTrenddiff 0.234
eHeightTrendratio 1.03571
eAspectMean 0.73514
eAspectStd 0.0822652
eAspectStdnorm 0.111904
eAspectMedian 0.729708
eAspectQuartdelta 0.126063
eAspectQuartdeltanorm 0.172758
eAspectKurt 2.18353
eAspectTrenddiff 0.0764371
eAspectTrendratio 1.1105
eSlantMean 0.324792
eSlantStd 0.180028
eSlantStdnorm 0.554287
eSlantMedian 0.338055
eSlantQuartdelta 0.248235
eSlantQuartdeltanorm 0.734303
eSlantKurt 5.00918
eSlantTrenddiff 0.121296
eRtopMean 0.907767
eRtopStd 0.0508215
eRtopStdnorm 0.0559852
eRtopMedian 0.91971
eRtopQuartdelta 0.0504335
eRtopQuartdeltanorm 0.0548363
eRtopKurt 2.92901
eRtopTrenddiff 0.0164787
eRbotMean 0.469708
eRbotStd 0.215285
eRbotStdnorm 0.458338
eRbotMedian 0.422222
eRbotQuartdelta 0.250887
eRbotQuartdeltanorm 0.594206
eRbotKurt 7.51535
eRbotTrenddiff -0.121366
eRrightMean 0.942724
eRrightStd 0.0389836
eRrightStdnorm 0.0413521
eRrightMedian 0.947822
eRrightQuartdelta 0.043385
eRrightQuartdeltanorm 0.0457734
eRrightKurt 3.37791
eRrightTrenddiff 0.00596284
eRleftMean 0.173421
eRleftStd 0.0579154
eRleftStdnorm 0.333958
eRleftMedian 0.175021
eRleftQuartdelta 0.0786589
eRleftQuartdeltanorm 0.449426
eRleftKurt 2.74812
eRleftTrenddiff -0.0091863
lDurationMean 0.919054
lDurationStd 0.188156
lDurationStdnorm 0.204728
lDurationMedian 0.935
lDurationQuartdelta 0.315
lDurationQuartdeltanorm 0.336898
lDurationKurt 1.87635
lDurationTrenddiff -0.1725
lDurationTrendratio 0.820779
lWidthMean 9.03746
lWidthStd 1.50401
lWidthStdnorm 0.166419
lWidthMedian 9.009
lWidthQuartdelta 1.638
lWidthQuartdeltanorm 0.181818
lWidthKurt 4.36716
lWidthTrenddiff 1.4625
lWidthTrendratio 1.17241
lHeightMean 12.9491
lHeightStd 1.74371
lHeightStdnorm 0.134659
lHeightMedian 12.753
lHeightQuartdelta 2.223
lHeightQuartdeltanorm 0.174312
lHeightKurt 6.11573
lHeightTrenddiff -0.117
lHeightTrendratio 0.99095
lAspectMean 0.699232
lAspectStd 0.0815473
lAspectStdnorm 0.116624
lAspectMedian 0.700855
lAspectQuartdelta 0.106054
lAspectQuartdeltanorm 0.151321
lAspectKurt 2.65885
lAspectTrenddiff 0.103608
lAspectTrendratio 1.16148
lSlantMean 0.498017
lSlantStd 0.0962545
lSlantStdnorm 0.193275
lSlantMedian 0.47541
lSlantQuartdelta 0.153186
lSlantQuartdeltanorm 0.322219
lSlantKurt 1.70926
lSlantTrenddiff 0.122795
lRtopMean 0.962078
lRtopStd 0.0302893
lRtopStdnorm 0.0314832
lRtopMedian 0.964286
lRtopQuartdelta 0.0378166
lRtopQuartdeltanorm 0.0392172
lRtopKurt 3.28698
lRtopTrenddiff 0.00189064
lRbotMean 0.250976
lRbotStd 0.0894845
lRbotStdnorm 0.356546
lRbotMedian 0.243902
lRbotQuartdelta 0.115506
lRbotQuartdeltanorm 0.473575
lRbotKurt 3.37208
lRbotTrenddiff -0.0336157
lRrightMean 0.97752
lRrightStd 0.0178422
lRrightStdnorm 0.0182526
lRrightMedian 0.981651
lRrightQuartdelta 0.02447
lRrightQuartdeltanorm 0.0249274
lRrightKurt 2.33093
lRrightTrenddiff 0.0112361
lRleftMean 0.114758
lRleftStd 0.047793
lRleftStdnorm 0.416466
lRleftMedian 0.0955882
lRleftQuartdelta 0.0735285
lRleftQuartdeltanorm 0.769221
lRleftKurt 2.25171
lRleftTrenddiff -0.0494348

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

Elel Segment 11

Elel Segment 12

FITTS Short Modified

meanTouchScore 0.933333
sumTouchScores 14
meanMovementTime 1.2925
numTouches 15
undershootPercentage 6.66667
overshootPercentage 0

fitts_short data not in signals file.

FITTS Long Modified

meanTouchScore 0.937936
sumTouchScores 10.3173
meanMovementTime 1.7155
numTouches 11
undershootPercentage 0
overshootPercentage 9.09091

fitts_long data not in signals file.

ZigZag

numZigzags 5
timePerZigzagMean 54.472
timePerZigzagCoV 0.233376
timePerZigzagSlope 0.0641063
meanError 2.4324
tremorFreq 5.95703
tremorRelPower 42.7778
tremorGyroAmpMean 0.0363817
tremorGyroAmpSlope 0.000375283
tremorGyroAmpCoV 0.472761
tremorCoordAmpMean 0.0760627
tremorCoordAmpSlope -0.00492679
tremorCoordAmpCoV 1.64273
tremorAccAmpMean 0.033339
tremorAccAmpSlope -0.00152306
tremorAccAmpCoV 0.449357
tremorPcRelVar 0.872861
tremorPcX 0.175526
tremorPcY -0.984475

ZigZag Segment 1

Duration 55.04 s, Accuracy Estimate 2.492 (lower is better)

ZigZag Segment 2

Duration 53.68 s, Accuracy Estimate 2.158 (lower is better)

ZigZag Segment 3

Duration 39.32 s, Accuracy Estimate 2.475 (lower is better)

ZigZag Segment 4

Duration 49.96 s, Accuracy Estimate 2.403 (lower is better)

ZigZag Segment 5

Duration 74.36 s, Accuracy Estimate 2.634 (lower is better)

ZigZag Offset

numZigzags 4
timePerZigzagMean 30.36
timePerZigzagCoV 0.286175
timePerZigzagSlope 0.0895916
zigzagHeightMean 70.3295
zigzagHeightCoV 0.0182808
zigzagHeightSlope 0.0141428
meanError 0.101029
tremorFreq 5.66406
tremorRelPower 40.147
tremorGyroAmpMean 0.0278779
tremorGyroAmpSlope -9.98291e-06
tremorGyroAmpCoV 0.405923
tremorCoordAmpMean 0.0803847
tremorCoordAmpSlope 0.00371078
tremorCoordAmpCoV 1.15005
tremorAccAmpMean 0.0838715
tremorAccAmpSlope 0.000262968
tremorAccAmpCoV 0.0784184
tremorPcRelVar 0.915758
tremorPcX 0.342571
tremorPcY 0.939492

ZigZag Offset Segment 1

Duration 23.8 s, Accuracy Estimate 0.118 (lower is better)

ZigZag Offset Segment 2

Duration 27.0 s, Accuracy Estimate 0.118 (lower is better)

ZigZag Offset Segment 3

Duration 43.16 s, Accuracy Estimate 0.074 (lower is better)

ZigZag Offset Segment 4

Duration 27.48 s, Accuracy Estimate 0.093 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.75}
RanFor {‘RanFor_class’: ‘NOT PD’, ‘RanFor_score’: 0.59}
BM_May22 {‘BM_May22_class’: ‘NOT PD’, ‘BM_May22_score’: 0.2965054263877145}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.8781800533552866}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘nonPD’, ‘BM_PD_Sep22_score’: 0.4339312493196158}